Exosome Research & Discovery

Exosomes and extracellular vesicles (EVs) are transforming biomarker discovery, liquid biopsy, cell therapy, and therapeutic development. InnovaPrep technologies enable rapid isolation and concentration of exosomes and EVs from biological specimens while supporting downstream molecular, protein, imaging, and functional analyses. Whether advancing research, diagnostic development, or therapeutic workflows, our solutions provide the speed, consistency, and reliability needed for modern EV applications.

 

The InnovaPrep® Concentrating Pipette™, powered by our patented Wet Foam Elution™ (WFE) technology, overcomes the challenges of traditional methods like ultracentrifugation and spin filters, which are time-consuming and often result in poor recovery. It enables the rapid isolation, concentration, and recovery of exosomes and extracellular vesicles (EVs) from urine, serum, plasma, conditioned media, and other biological fluids while helping preserve vesicle integrity for downstream analysis. For applications involving extracellular vesicles and mammalian cells, PBS-X WFE fluid is available as a gentle recovery option designed to support optical, cellular, and downstream analytical workflows. As the future of personalized medicine hinges on understanding exosomes, our innovative tools ensure you stay at the forefront of this groundbreaking field

Experience the Difference

Title

Our solutions deliver the precision and reliability essential for advancing exosome research, manufacturing or facilitating the discovery of novel biomarkers and therapeutic targets. 

Rapid and Efficient EV Isolation:  Results in under 10 minutes

Simple Workflow: No ultracentrifugation required

High Recovery in Small Elution Volumes: Recover concentrated exosomes and EVs suitable for downstream characterization and analytical workflows.

Broad Downstream Compatibility: Compatible with molecular assays, protein analysis, flow cytometry, nanoparticle characterization (NTA/F-NTA), electron microscopy, sequencing, and other EV analytical workflows.

Recommended Wet Foam Elution™ Fluid

PBS-X™ Elution Fluid is recommended for many extracellular vesicle (EV), exosome, and mammalian cell workflows where gentle recovery and compatibility with downstream analytical methods are important.

LEARN ABOUT ELUTION FLUID SELECTION

Method Comparison

Parameter

InnovaPrep

Centricon Plus-70 (100 kDa)

Ultracentrifugationa

Hands-on Time

< 5 minutes

> 10 min

> 1 hour

Total Time

5-21 minutes

> 1 hour

> 4 hour

Number of Samples in Parallel

1

6 to 8

6 to 8

Skill Level Required

Moderate

High

High

Maximum Sample Volume (Urine)

100+ mL

70 mL

50 µL

Final Sample Volume

150 to 1,000a

350 µL

500 µL

Theoretical Maximum Concentration Factor

~ 1,500xb

2oox

100x

Starting specimen volumes and final "elution volume" are customizable. The above example was based on concentrating 300 mL of urine into a final 200 µL volume.

applications & uses

Scientific Information
The aim of this testing was to investigate ways to replace or optimize upon the widely used ultracentrifuge method for isolating exosomes (Extracellular Shed Vesicles) for basic science applications as the high forces generated using ultracentrifugation can negatively affect exosome morphology by impacting exosome function - and thus a gentler process of isolation is needed.
Scientific Information
The Concentrating Pipette was used to isolate and concentrate bacteriophage used as a therapeutic approach to combat infections caused by antimicrobial-resistant bacteria in cystic fibrosis patients. “The main advantage of the Concentrating Pipette was that it allowed us to easily concentrate a large sample volume (900 mL), which can be difficult to manage with traditional methods such as ultracentrifugation”,
Scientific Information

We’re thrilled to announce that InnovaPrep has been selected by BioTools Innovator,  as one of the Top 31 Life Science Tools and Diagnostics Companies for their 2025 cohort! BioTools Innovator is the first ever accelerator focused on Life Science research tools.

This prestigious selection places us among an elite group of innovators driving advancements in diagnostics, therapeutics, and life science research.

what sets us apart

gentle recovery

Designed to help preserve extracellular vesicle integrity for downstream characterization.

supports diverse ev workflows

Applicable across biomarker discovery, diagnostics, therapeutic development, and extracellular vesicle research.

 

streamlined workflow

Simple workflow with consistent, reliable results

The concentrating pipette maybe a faster alternative method to isolate exosomes with performance comparable to ultracentrifugation. 

Fong et Al. Lawrence Livermore National Lab 

Researchers use InnovaPrep technologies across a broad range of extracellular vesicle applications including exosome isolation, biomarker discovery, liquid biopsy, cell therapy research, therapeutic development, molecular biology, proteomics, flow cytometry, nanoparticle tracking analysis (NTA), sequencing, and electron microscopy. Rapid concentration combined with Wet Foam Elution™ provides a streamlined alternative to traditional ultracentrifugation workflows for many research applications.

Related Products

CP Select™ Concentrating Pipette

Experience the efficiency of the FluidPrep™ Concentrating Pipette System by InnovaPrep, engineered to simplify workflows and boost assay sensitivity. This system is highly effective in recovering microorganisms and particles, including bacteria, parasites, molds, fungal spores, whole cells, viruses, and synthetic particles, from sample volumes between 0.5 mL and 5 L.

The one-pass method uses robust filtration followed by instant sample recovery using InnovaPrep's patented Wet Foam Elution™ process delivering a highly concentrated sample ideal for detection by culture, PCR, sequencing, and more – with unprecedented speed and efficiency. For applications needing rapid, reliable sample concentration, this system provides a faster, simpler alternative to traditional culture enrichment, centrifugation, and ultracentrifugation methods.

Includes: 

  • CP Select Instrument
  • Accessory Kit  -  Includes the Storage Fluid Adapter, Permeate Line, Maintenance Tip
  • One-year manufacturer warranty

Consumable supplies (pictured) and optional accessories sold separately.

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FluidPrep™ Mini CPT - Irradiated

Single-use, Irradiated, Mini Concentrating Pipette Tips (CPTs) are available in a variety of formats. Selecting the ideal CPT for use with the FluidPrep Concentrating Pipette System is crucial to achieving optimal performance - both in terms of speed and concentration factor of your target. 

 

Selecting the Right CPT - Factors to consider

1 - Pore Size based on Nature and Size of Target Particle

CPTs are available in four pore sizes – Ultra, 0.05 µm, 0.2 µm, and 0.45 µm to accommodate the wide range of target particle types and sizes. 

*Volume and flow rates will vary by matrix and selected menu settings

2 - Surface Area by Sample Matrix and Sample Volume

The complexity of your sample and overall volume to be processed will influence the speed and overall volume that can be processed effectively. Two options are available.

  • Standard length CPTs - Membrane surface area is 98 cm² nominal. Recommended for sample volumes over 200 mL and/or more complex or turbid matrices.
  • Mini 25 CPTs  - The membrane surface area is 25 cm² nominal and capable of smaller elution volumes with optimized menu settings. Recommended for sample volumes 200 mL or less and of low complexity/turbidity. Short-walled sample containers and the CP Sample Carousel are required for use.

As a general Rule of Thumb, we recommend using the smallest tip that provides the desired concentration factor for your application.

3 - Packaging Format by Target Application

All products are produced aseptically in a cleanroom environment. Understanding your downstream application will help identify which package format is best suited.

  • Non-irradiated CPTs -Bulk packaged and suitable for most applications due to the inherent low background.  Recommended if target organisms are non-ubiquitous or using selective assays.
  • Irradiated CPTs  - Individually wrapped and irradiated to provide added protection against bioburden. Best for culture-based downstream applications.

Tips are designed for use with the CP Select (sold separately) 

We recommend use with the CP sample carousel item #HC08042, and our selection of short-walled sample containers, Sample Cup Flip-Top 200ml item #HC08040-10, Sample Vial Flip-Top 10 mL item # HC08041-10, and Sample Cup with Conical Bottom item #AC08106-10.

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Application Notes

Explore our detailed application notes to learn how you can use our innovative solutions to optimize your sample processing.

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