Biomarker Discovery & Diagnostics

Explore the Versatility of InnovaPrep’s Technology to Streamline Concentration, Isolation and Purification of Biological Particles Ranging from Viruses to Cell Fragments, Extracellular Vesicles, Mammalian and Bacterial Cells, Enabling Detection and Quantification of Disease Biomarkers in Diagnostic Assays. 

In the quest for precision medicine, the discovery and detection of biomarkers are critical. InnovaPrep’s innovative technologies offer unparalleled simplicity and efficiency in isolating and concentrating biological particles ranging from phage to cell fragments, extracellular vesicles, mammalian and bacterial cells. Our solutions empower researchers and clinicians to detect disease early, monitor therapeutic responses, and develop targeted treatments. Whether you’re working on cancer diagnostics, infectious disease, or personalized medicine, InnovaPrep provides the tools you need to advance biomarker research. 

applications & uses

Scientific Information
The Concentrating Pipette was used to isolate and concentrate bacteriophage used as a therapeutic approach to combat infections caused by antimicrobial-resistant bacteria in cystic fibrosis patients. “The main advantage of the Concentrating Pipette was that it allowed us to easily concentrate a large sample volume (900 mL), which can be difficult to manage with traditional methods such as ultracentrifugation”,
Scientific Information
The aim of this testing was to investigate ways to replace or optimize upon the widely used ultracentrifuge method for isolating exosomes in search of a gentler method, as the high forces generated using ultracentrifugation can affect exosome morphology and can negatively impact exosome function and thus need a gentler process of isolation.
Scientific Information
This testing indicates the gentle nature of the Wet Foam Elution technology for retaining viability during the Concentrating Pipette's elution process using our standard PBS elution buffer.

what sets us apart

gentle process

Maintains integrity of cells and viruses, enabling viable studies and culture.

versatile applications

Ideal for broad range of samples, targets and use cases. 

streamlined workflows

Simple workflow with consistent, reliable results

The concentrating pipette may be a faster alternative method to isolate exosomes with performance comparable to ultracentrifugation.

Fong et Al. Lawrence Livermore National Lab 

Related Products

CP Select™ Concentrating Pipette

Experience the efficiency of the FluidPrep™ Concentrating Pipette System by InnovaPrep, engineered to simplify workflows and boost assay sensitivity. This system is highly effective in recovering microorganisms and particles, including bacteria, parasites, molds, fungal spores, whole cells, viruses, and synthetic particles, from sample volumes between 0.5 mL and 5 L.

The one-pass method uses robust filtration followed by instant sample recovery using InnovaPrep's patented Wet Foam Elution™ process delivering a highly concentrated sample ideal for detection by culture, PCR, sequencing, and more – with unprecedented speed and efficiency. For applications needing rapid, reliable sample concentration, this system provides a faster, simpler alternative to traditional culture enrichment, centrifugation, and ultracentrifugation methods.

Includes: 

  • CP Select Instrument
  • Accessory Kit  -  Includes the Storage Fluid Adapter, Permeate Line, Maintenance Tip
  • One-year manufacturer warranty

Consumable supplies (pictured) and optional accessories sold separately.

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FluidPrep™ Elution Buffer (CP Select™)

For use with CP Select™ only

 

Optimize the performance of your FluidPrep™ Concentrating Pipette System with our specially formulated Elution Buffers. Designed to enhance concentration efficiency through our patented Wet Foam Elution™ process, choosing the right elution buffer ensures optimal recovery, target integrity, and seamless compatibility with downstream applications. Use our guide to select the best elution buffer for your specific needs.

Note:
PBS, PBS-X and Tris Elution Fluids are irradiated and have min. of 90 days shelf-life at time of shipment. 
DMEM Elution Fluid is available in a 5-pack only, is non-irradiated. Store refrigerated.

 

Expert Support - If you need assistance in selecting the most suitable CPTs and elution buffer for your CP Select system, our team of experts is ready to help. Contact us for tailored advice and support to ensure optimal performance and results.

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FluidPrep™ Mini CPT - Irradiated

Single-use, Irradiated, Mini Concentrating Pipette Tips (CPTs) are available in a variety of formats. Selecting the ideal CPT for use with the FluidPrep Concentrating Pipette System is crucial to achieving optimal performance - both in terms of speed and concentration factor of your target. 

 

Selecting the Right CPT - Factors to consider

1 - Pore Size based on Nature and Size of Target Particle

CPTs are available in four pore sizes – Ultra, 0.05um, 0.2um and 0.45um to accommodate the wide range of target particle types and sizes. 

*Volume and flow rates will vary by matrix and selected menu settings

2 - Surface Area by Sample Matrix and Sample Volume

The complexity of your sample and overall volume to be processed will influence the speed and overall volume that can be processed effectively. Two options are available.

  • Standard length CPTs - Membrane surface area is 98 cm²nominal. Recommended for sample volumes over 200 mL and/or more complex or turbid matrices.
  • Mini 25 CPTs  - The membrane surface area is 25 cm²nominal and capable of smaller elution volumes with optimized menu settings. Recommended for sample volumes 200 mL or less and of low complexity/turbidity. Short-walled sample containers and the CP Sample Carousel are required for use.

As a general Rule of Thumb, we recommend using the smallest tip that provides the desired concentration factor for your application.

3 - Packaging Format by Target Application

All products are produced aseptically in a cleanroom environment. Understanding your downstream application will help identify which package format is best suited.

  • Non-irradiated CPTs -Bulk packaged and suitable for most applications due to the inherent low background.  Recommended if target organisms are non-ubiquitous or using selective assays.
  • Irradiated CPTs  - Individually wrapped and irradiated to provide added protection against bioburden. Best for culture-based downstream applications.

Tips are designed for use with the CP Select (sold separately) 

We recommend use with the CP sample carousel item #HC08042, and our selection of short-walled sample containers, Sample Cup Flip-Top 200ml item #HC08040-10, Sample Vial Flip-Top 10ml item # HC08041-10, and Sample Cup with Conical Bottom item #AC08106-10.

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Application Notes 

Explore our detailed application notes to learn how you can use our innovative solutions to optimize your sample processing. 

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Research Highlights

Explore research highlights to learn more about how clients use our products.

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